149 TOWNSEND.qxd
نویسنده
چکیده
Dr Townsend graduated with Honours from the University of Queensland in 1989. During his anaesthesia training in Brisbane, he was awarded both the Renton and Cecil Grey Prizes. While a staff specialist anaesthetist at Prince Charles Hospital in Brisbane from 1999 to 2001 he gained experience working with cardiac surgical patients and aspects of managing shock states with circulatory assist devices. He is now a full time intensivist at The Royal Melbourne Hospital, where he is undertaking a Doctorate of Medicine through the University of Melbourne.
منابع مشابه
Autoregulation of glypican-1 by intronic microRNA-149 fine tunes the angiogenic response to FGF2 in human endothelial cells.
MicroRNA-149 (miR-149) is located within the first intron of the glypican-1 (GPC1) gene. GPC1 is a low affinity receptor for fibroblast growth factor (FGF2) that enhances FGF2 binding to its receptor (FGFR1), subsequently promoting FGF2-FGFR1 activation and signaling. Using bioinformatic approaches, both GPC1 and FGFR1 were identified and subsequently validated as targets for miR-149 (both the ...
متن کاملMicroRNA-149 Increases the Sensitivity of Colorectal Cancer Cells to 5-Fluorouracil by Targeting Forkhead Box Transcription Factor FOXM1.
BACKGROUND/AIMS Previously, we have shown that microRNA (miR)-149 suppresses the migration and invasion of colorectal cancer (CRC) cells by targeting forkhead box transcription factor (FOXM1). However, the roles of miR-149 in the chemoresistance of CRC cells to 5-Fluorouracil (5-FU) is unclear. The aim of this study is to investigate whether miR-149 targets FOXM1 to regulate the 5-FU resistance...
متن کاملmicroRNA-149 targets caspase-2 in glioma progression
Malignant gliomas are the most common form of intrinsic primary brain tumors worldwide. Alterations in microRNAs play a role in highly invasive malignant glioma, but detail mechanism still unknown. In this study, the role and mechanism of microRNA-149 (miR-149) in glioma are investigated. We show that miR-149 is expressed at substantially higher levels in glioma than in normal tissues. Stable o...
متن کاملBiochemical Effects Current Trends in Fluorine Research
s Fluoride 40(2)149–154 April-June 2007 Abstracts 149 149
متن کاملLow MiR-149 expression is associated with unfavorable prognosis and enhanced Akt/mTOR signaling in glioma.
MicroRNAs (miRs) play critical roles in the progression of glioma. Previous in vitro studies have described the anti-tumor role of miR-149 in cancer cells including glioma. In this study, we aimed to investigate whether miR-149 is associated with the prognosis of glioma patients. A total of 163 glioma patients who underwent tumor resection were included in our follow-up study. We found that the...
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